Review Article

Retraction in process: Understanding the Role of Genetics in Tumour and Cancer Biology

Abdulaziz Asiri^*, Amer Al Ali, Mohammed H. Abu-Alghayth

Adv. life sci., vol. 12, no. 1, pp. 35-48, February 2025
*^- Corresponding Author: Abdulaziz Asiri (Email: amfasiri@ub.edu.sa)
Authors' Affiliations

Editorial Note: This manuscript has post-publication change in the acknowledgement section.

Editorial Expression of Concern:

18 May 2025: Following publication of this paper, the internal audit (consequent to concerns on quality raised by Web of Science) notified Advancements in Life Sciences about missing record of the Turnitin Originality / AI Reports. By this Editorial Expression of Concern, we alert the scientific community of the errors as we reconcile the records.

Editorial Note:

28 May 2025: While reconciling the record of Turnitin originality analysis, 49% content of this article was found generated using AI tool/s without clear disclosure along with similarity on more than 4% with at least one source published prior to this article. 

Editorial board of Advancements in Life Sciences has started the process of retracting this article due to the above post-publication findings. The process shall be concluded after registering responses from the authors. Meanwhile, full text of the article shall remain unavailable for citations (this notice has been updated following insights derived from relevant COPE cases and the industry standards).

Abstract
Introduction
Methods
Discussion
Conclusion
References 

Abstract

The interplay between genetics and cancer has been a focal point of research for decades, leading to profound understandings into the molecular mechanisms driving tumorigenesis. In this comprehensive review article, we explore the genetic basis of cancer, encompassing the diverse array of alterations that underline oncogenic transformation. From oncogenes to tumor suppressor genes, and from point mutations to chromosomal rearrangements, we delve into the molecular hallmarks of cancer and their implications for diagnosis, treatment, and prevention. Drawing on recent advancements in genomic technologies, we discuss the role of next-generation sequencing, single-cell sequencing, and computational modeling in unraveling the complexity of cancer genetics. Furthermore, we examine the clinical implications of genetic predisposition to cancer, highlighting the importance of genetic testing and counselling in cancer risk assessment and management. Through an exploration of tumor heterogeneity, clonal evolution, and therapeutic resistance, we underscore the challenges and opportunities in precision oncology. Finally, we discuss future directions in cancer genetics research, including precision prevention strategies and ethical considerations.

Keywords: Cancer Genetics; Oncogenes; Tumor Suppressor Genes; Genetic Alterations; Precision Oncology; Clonal Evolution