In line with the Policy on Pre-Publication Listing of Accepted Manuscripts, part of the editorial reforms adopted on 01 August 2025, here is the list of papers which have been accepted for publication and will appear in future issues of the journal after being typeset and copyedited.
Synthesis, Characterization, and Cytotoxic Activity Study of Ni (II), Cu (II), and Metal Complexes with New Schiff Base on Hepatocellular Carcinoma (HCAM) Cancer Cell
Zaid N. O. Al-husseini, Jasim M. S. Alshawi
Abstract
Background: Among the most important alkyl groups of Schiff bases are those that contain heterocyclic atoms, such as sulfur or oxygen, and are called heterocyclic compounds. These compounds are considered to form complexes with metallic elements and have high biological effectiveness, such as anti-cancer.
Methods: In this work, a novel ligand was synthesized by reacting O-Phenylenediamine (OPD) and 4-Nitro-o-phenylenediamine with thiophene-2-carboxaldehyde. Transition metal complexes of Ni (II) and Cu (II) were synthesized using a 1:1 molar ratio of metal chlorides to the ligand (M: L).
Results: The ligand and its metal complexes were characterized using a variety of spectroscopic and analytical methods. The results showed that a tetrahedral geometry is favored for the metal complexes.
Conclusion: Schiff base and its metal complexes were tested for their cytotoxic potential against hepatoma cellular carcinoma (HCAM) cancer cells.
Estimation of (IgG and IgA)antibodies and complement proteins (C3 and C4) levels in obese people sera in Diyala governorate
Marwa Yahya Mohamed Khairy, Maha Falih Nazzal
Abstract
Background: Obesity is a medical condition that means the accumulation of excess fat in the body to the extent that it has a negative effect on health. It leads to a decrease in the expected average age of individuals or leads to an increase in medical diseases. The recent study aimed to explore the levels of complement proteins C3 and C4 and the antibodies IgA and IgG in the serum of obese patients whose Body Mass Index (BMI) was 40 kg/m2 or more in comparison with the control group who had the ideal weight.
Methods: The study was carried out in Baquba Teaching Hospital in Diyala/ Iraq, during the limited period from September 2022 to November 2022. The patients’ sample consisted of only 50 blood samples that were taken from individuals suffering from obesity. The total sample was distributed into (9, 18%) males and (41, 82%) females. Their ages ranged between 15 and 55. Concerning the healthy (or control) group, the sample involved 38 individuals who were apparently healthy.
Results: The study showed that the mean of infection among females was higher than among males. Also, it was shown that the age category (15-25) was the highest category afflicted with obesity among females and males. The serum was separated, and the Single Immunodiffusion method was used for examining the under study complement proteins (C3 & C4), and Immunoglobulins (IgA and IgG), and this was based on the precipitate ring. The results of the recent study revealed an increase in C3 level among the obese individuals (2.02 ± 178.06) mg/dl in comparison with the control (0.69 ± 27.87) mg/dl. In addition, there was an increase in the C4 level in the serum of the obese individuals (1.13 ± 74-91) mg/dl in comparison with the control (0.43 ± 12.43) mg/dl at a significant level (p<0.05). Regarding the levels of Immunoglobulins, there is an increase in the IgA level in the serum of the obese individuals (9.28±697.86) mg/dl in comparison with the control (2.66±84.77) mg/dl. Also, there was an increase in the IgG level (40.26±2067.20) in comparison with the control (20.73 ± 412.38) mg/dl at the significant level (p < 0.05).
Conclusion: There is an increase in the C3 and C4 levels in the obese group compared to the control group, and there is an increase in the IgA and IgG levels in the obese group compared to the control group
Synthesis, Characterization and Anticancer Study of New 4-{[3-(2-hydroxyphenyl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]carbonoimidoyl}benzene-1,3-diol and Their Transition Metal Complexes
Safaa. H. Nasir, Ibrahim. A. Flifel
Abstract
Background: The present study included the synthesis of a new 4-{[3-(2-hydroxyphenyl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]carbonoimidoyl}benzene-1,3-diol, and its complexes with Ni(ІІ), Co(ІІ), Cu(ІІ), Fe(ІІІ), and Cr(ІІІ) ions were synthesized.
Methods: Characterizations were conducted by conductance measurements, mass spectra, 1H NMR, FTIR, and elemental analyses.
Results: Their conductance confirmed their non-electrolytic behavior. The hyper-chem study of transition metal complexes suggests octahedral geometry for Fe+3 and Cr+3 ions, square planar geometry for Ni+2, Cu+2, and CO+2, suggesting tetrahedral geometry. The ligand was tested as an anticancer, and the prepared ligand showed good anticancer activity.
Conclusion: The new ligand 4-{[3-(2-hydroxyphenyl)-5-sulfanyl-4H-1,2,4-triazol-4-yl]carbonoimidoyl}benzene-1,3-diol, the spectroscopic data display the involvement of CH=N groups in coordination to the central transition metal ion. The molar conductance confirms that all the complexes are non-electrolytes. According to HyperChem, characterization of transition metal complexes shows that octahedral geometry for Fe (III), Cr (III), tetrahedral geometry for Cu (II), Co (II), and square planar geometry was suggested for Ni (II). (L) was successfully synthesized. It acts like a bidentate ligand and a tridentate ligand.
Molecular detection of some efflux pump genes in clinical isolates of MDR Pseudomonas aeruginosa
Seham Ahmed Yousef, Muna T. Al-Musawi, Ibtesam Badday Hassan
Abstract
Background: Pseudomonas aeruginosa (P. aeruginosa) is an opportunistic pathogen that is a leading cause of many types of infections, including acquired infections and healthcare-associated infections. In general, this organism is highly resistant to different classes of antimicrobials through different mechanisms that represent a major concern in the treatment of infections in hospitals. Therefore, this study aimed to detect the genes of efflux pumps, including MexAB, MexXy, MexC, and OperM in antibiotic-resistant P. aeruginosa isolated from different clinical samples in Diyala Province using PCR technology.
Methods: The study included 50 isolates obtained from patients with different infections. This study was conducted during the period from November 2022 to March 2023, and all isolates were diagnosed with the Vitek system.
Results: The results according to the total bacterial growth showed that the rate of P. aeruginosa was 50 isolates, of which males were 23 (46%) and females 27 (54%). A total of 20 MDR isolates were selected by testing all isolates for 10 different class of antimicrobials, using the method of Kirby-Bauer disk diffusion. The molecular results of the efflux pump genes in this study showed that 10 20/(50%) of the isolates contained the MexB gene, while the isolates did not contain the MexA gene, and all isolates contained the MexC and MexY genes by 20/20 (100%), and two isolates (20%) only contained the MexX gene, while only one isolate (10%) contained the OprM gene.
Conclusion: The current study showed a rise in the spread of Mex efflux pump genes between the MDR isolates of P. aeruginosa bacteria that we obtained from different clinical samples in Diyala province, and therefore, the isolated positive efflux pumps were detected in this study and this indicates the extent of enhanced prevention and severe control of this infection.
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